Dixon, J.C.;
(2005)
The influence of fetal growth restriction and infection on the cerebral metabolic response to acute hypoxia.
Doctoral thesis , University of London.
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Abstract
Intrauterine growth restriction and infection are significant risk factors for neonatal hypoxic ischaemic encephalopathy in term neonates. It was hypothesised that these two factors increase the susceptibility of the fetal brain to hypoxic ischaemic damage by their influence on cerebral metabolism and development. Cerebral energy and structural metabolites in a late gestation in-ovo chick embryo model of acute hypoxia and fetal growth restriction were measured non invasive using proton and phosphorus Magnetic Resonance Spectroscopy. The influence of fetal growth restriction and acute hypoxia on cerebral metabolites was assessed. In addition, the individual and combined effects of growth restriction, acute hypoxia and systemic infection on morphological markers of neuronal injury were assessed.
| Type: | Thesis (Doctoral) |
|---|---|
| Title: | The influence of fetal growth restriction and infection on the cerebral metabolic response to acute hypoxia. |
| Identifier: | PQ ETD:592807 |
| Open access status: | An open access version is available from UCL Discovery |
| Language: | English |
| Additional information: | Thesis digitised by Proquest |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Maternal and Fetal Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1445485 |
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