Sandhu, S.S.; (2006) To investigate using morphometric and immunohistochemical criteria the relationship between prostatic intra-epithelial neoplasia and prostate cancer. Doctoral thesis , University of London.

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Abstract

Prostatic Intraepithelial Neoplasia (PIN) is a putatitive precursor of prostate carcinoma (CaP). PIN is defined as an abnormal proliferation where the cellular changes exhibit the cytological changes of cancer, but retain a basal cell layer. Using radical prostatectomy specimens we have studied the relationship between PIN and carcinoma of the prostate. Method: This study was divided into two parts: 1) Step sections from 76 consecutive radical prostatectomy specimens were examined prospectively. Using planimetry software the total volume of the gland, the volume of cancer, the volume of benign tissue, and the volume of PIN was calculated. These volumes were compared to serum PSA. 2) The expression of P53, bcU. baxaiPha, and Ki-67 was measured using semi quantitative immunohistochemistry in 92 hormone naive specimens as well as specimens from 14 patients who had received androgen ablation. Benign prostate specimens obtained from 19 patients were used as controls. This was carried out retrospectively. Results: The mean weight of the prostate gland was 61.3 (range = 26 - 173) g, the mean calculated total volume of the gland was 50.9 (range 19.4 -155.5) mis, the mean volume of cancer was 2.5 (range = 0.09 - 15) mis, the mean volume of PIN was 0.53 (range = 0 - 2.7) mis, and the mean volume of benign tissue in each gland was 47.5 (range = 13.3 - 153.4) mis. The mean value for the PSA= 9.1 (range = 3-45) ng/ml.

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