Paul, DS;
Beck, S;
(2014)
Advances in epigenome-wide association studies for common diseases.
Trends in Molecular Medicine
, 20
(10)
pp. 541-543.
10.1016/j.molmed.2014.07.002.
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Abstract
Epigenome-wide association studies (EWASs) provide a systematic approach to uncovering epigenetic variants underlying common diseases. Discoveries have shed light on novel molecular mechanisms of disease and enabled the application of epigenetic variants as biomarkers. Here, we highlight the recent advances in this emerging line of research and discuss key challenges for current and future studies.
| Type: | Article |
|---|---|
| Title: | Advances in epigenome-wide association studies for common diseases. |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.molmed.2014.07.002 |
| Publisher version: | http://dx.doi.org/10.1016/j.molmed.2014.07.002 |
| Language: | English |
| Additional information: | © 2014 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/). http://dx.doi.org/ 10.1016/j.molmed.2014.07.002 |
| Keywords: | DNA methylation, EWAS, GWAS, biomarker, disease mechanism |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Cancer Bio |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1437216 |
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