Woolf, DK;
Williams, NR;
Bakshi, R;
Madani, SY;
Eaton, DJ;
Fawcitt, S;
Pigott, K;
... Keshtgar, M; + view all
(2014)
Biological dosimetry for breast cancer radiotherapy: a comparison of external beam and intraoperative radiotherapy.
Springerplus
, 3
, Article 329. 10.1186/2193-1801-3-329.
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Abstract
External beam radiotherapy (EBRT) is the gold standard adjuvant treatment after breast conserving surgery although a recent phase 3 trial has shown the non-inferiority of intraoperative radiotherapy (IORT). Radiation exposure of the heart and cardiac vessels causes an increase in morbidity and mortality following EBRT for breast cancer. We have used γ-H2AX foci formation in peripheral blood lymphocytes as a surrogate marker of dose delivered to the heart and great vessels and have assessed the feasibility of using this technique for biological dosimetry.
| Type: | Article |
|---|---|
| Title: | Biological dosimetry for breast cancer radiotherapy: a comparison of external beam and intraoperative radiotherapy |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1186/2193-1801-3-329 |
| Publisher version: | http://dx.doi.org/10.1186/2193-1801-3-329 |
| Language: | English |
| Additional information: | © 2014 Woolf et al.; licensee Springer. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. PMCID: PMC4093905 |
| Keywords: | Breast cancer, Cardiac toxicity, H2AX, Intraoperative radiotherapy |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1436690 |
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