Mehta, V; Abi-Nader, KN; Shangaris, P; Shaw, SW; Filippi, E; Benjamin, E; Boyd, M; ... David, AL; + view all Mehta, V; Abi-Nader, KN; Shangaris, P; Shaw, SW; Filippi, E; Benjamin, E; Boyd, M; Peebles, DM; Martin, J; Zachary, I; David, AL; - view fewer (2014) Local Over-Expression of VEGF-DΔNΔC in the Uterine Arteries of Pregnant Sheep Results in Long-Term Changes in Uterine Artery Contractility and Angiogenesis. PLoS One , 9 (6) , Article e100021. 10.1371/journal.pone.0100021.

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Abstract

The normal development of the uteroplacental circulation in pregnancy depends on angiogenic and vasodilatory factors such as vascular endothelial growth factor (VEGF). Reduced uterine artery blood flow (UABF) is a common cause of fetal growth restriction; abnormalities in angiogenic factors are implicated. Previously we showed that adenovirus (Ad)-mediated VEGF-A165 expression in the pregnant sheep uterine artery (UtA) increased nitric oxide synthase (NOS) expression, altered vascular reactivity and increased UABF. VEGF-D is a VEGF family member that promotes angiogenesis and vasodilatation but, in contrast to VEGF-A, does not increase vascular permeability. Here we examined the effect of Ad.VEGF-DΔNΔC vector encoding a fully processed form of VEGF-D, on the uteroplacental circulation.

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