Bizrah, M;
Dakin, SC;
Guo, L;
Rahman, F;
Parnell, M;
Normando, E;
Nizari, S;
... Cordeiro, MF; + view all
(2014)
A semi-automated technique for labeling and counting of apoptosing retinal cells.
BMC Bioinformatics
, 15
(1)
169 -180.
10.1186/1471-2105-15-169.
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Abstract
Retinal ganglion cell (RGC) loss is one of the earliest and most important cellular changes in glaucoma. The DARC (Detection of Apoptosing Retinal Cells) technology enables in vivo real-time non-invasive imaging of single apoptosing retinal cells in animal models of glaucoma and Alzheimer's disease. To date, apoptosing RGCs imaged using DARC have been counted manually. This is time-consuming, labour-intensive, vulnerable to bias, and has considerable inter- and intra-operator variability
| Type: | Article |
|---|---|
| Title: | A semi-automated technique for labeling and counting of apoptosing retinal cells |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1186/1471-2105-15-169 |
| Publisher version: | http://dx.doi.org/10.1186/1471-2105-15-169 |
| Additional information: | © 2014 Bizrah et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1432362 |
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