Kiguli, S;
Akech, SO;
Mtove, G;
Opoka, RO;
Engoru, C;
Olupot-Olupot, P;
Nyeko, R;
... Maitland, K; + view all
(2014)
WHO guidelines on fluid resuscitation in children: missing the FEAST data.
BMJ
, 348
, Article f7003. 10.1136/bmj.f7003.
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Abstract
The World Health Organization recommendations on management of common childhood illnesses affect the lives of millions of children admitted to hospital worldwide. Its latest guidelines,1 released in May 2013, continue to recommend rapid fluid resuscitation for septic shock, even though the only large controlled trial of this treatment (Fluid Expansion as a Supportive Treatment (FEAST) found that it increased the risk of death in African children.2 A subsequent systematic review of bolus resuscitation in children with shock resulting from severe infection also did not support its use.3 Failure to take this evidence into account is not consistent with WHO’s commitment to systematically and transparently assess evidence using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) process when producing guidelines and could endanger the lives of children.
| Type: | Article |
|---|---|
| Title: | WHO guidelines on fluid resuscitation in children: missing the FEAST data. |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1136/bmj.f7003 |
| Publisher version: | http://dx.doi.org/10.1136/bmj.f7003 |
| Language: | English |
| Additional information: | This is an Open Access article distributed in accordance with the Creative Commons Attribution (CC BY 3.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/3.0/ |
| Keywords: | Child, Child, Preschool, Fluid Therapy, Humans, Practice Guidelines as Topic, Shock, Septic, World Health Organization |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1429311 |
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