Tredwin, CJ;
Young, AM;
Abou Neel, EA;
Georgiou, G;
Knowles, JC;
(2014)
Hydroxyapatite, fluor-hydroxyapatite and fluorapatite produced via the sol-gel method: dissolution behaviour and biological properties after crystallisation.
Journal of Materials Science - Materials in Medicine
, 25
(1)
47 - 53.
10.1007/s10856-013-5050-y.
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Abstract
Hydroxyapatite (HA), fluor-hydroxyapatite (FHA) with varying levels of fluoride ion substitution and fluorapatite (FA) were synthesised by the sol–gel method as possible implant coating or bone-grafting materials. Cal- cium nitrate and triethyl phosphite were used as precursors under an ethanol–water based solution. Different amounts of ammonium fluoride were incorporated for the preparation of the FHA and FA sol–gels. After heating and powdering the sol–gels, dissolution behaviour was assessed using ion chromatography to measure Ca2+ and PO 4 3- ion release. Biological behaviour was assessed using cellular prolifera- tion with human osteosarcoma cells and alamarBlue (TM) assay. Statistical analysis was performed with a two way analysis of variance and post hoc testing with a Bonferroni correction. Increasing fluoride substitution into an apatite structure decreased the dissolution rate. Increasing the firing temperature of the HA, FHA and FA sol–gels up to 1,000C decreased the dissolution rate. There was significantly higher cellular proliferation on highly substituted FHA and FA than on HA or Titanium. The properties of an implant coating or bone grafting material can be tailored to meet specific requirements by altering the amount of fluoride that is incorporated into the original apatite structure. The dis-solution behaviour can further be altered by the temperature at which the sol–gel is fired.
| Type: | Article |
|---|---|
| Title: | Hydroxyapatite, fluor-hydroxyapatite and fluorapatite produced via the sol-gel method: dissolution behaviour and biological properties after crystallisation |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s10856-013-5050-y |
| Publisher version: | http://dx.doi.org/10.1007/s10856-013-5050-y |
| Language: | English |
| Additional information: | © 2013 The Authors. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Biomaterials and Tissue Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1423400 |
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