Sandeman, SR;
Howell, CA;
Phillips, GJ;
Zheng, Y;
Standen, G;
Pletzenauer, R;
Davenport, A;
... Mikhalovsky, SV; + view all
(2014)
An adsorbent monolith device to augment the removal of uraemic toxins during haemodialysis.
J Mater Sci Mater Med
, 25
(6)
1589 - 1597.
10.1007/s10856-014-5173-9.
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Abstract
Adsorbents designed with porosity which allows the removal of protein bound and high molecular weight uraemic toxins may improve the effectiveness of haemodialysis treatment of chronic kidney disease (CKD). A nanoporous activated carbon monolith prototype designed for direct blood contact was first assessed for its capacity to remove albumin bound marker toxins indoxyl sulphate (IS), p-cresyl sulphate (p-CS) and high molecular weight cytokine interleukin-6 in spiked healthy donor studies. Haemodialysis patient blood samples were then used to measure the presence of these markers in pre- and post-dialysis blood and their removal by adsorbent recirculation of post-dialysis blood samples. Nanopores (20-100 nm) were necessary for marker uraemic toxin removal during in vitro studies. Limited removal of IS and p-CS occurred during haemodialysis, whereas almost complete removal occurred following perfusion through the carbon monoliths suggesting a key role for such adsorbent therapies in CKD patient care.
| Type: | Article |
|---|---|
| Title: | An adsorbent monolith device to augment the removal of uraemic toxins during haemodialysis. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s10856-014-5173-9 |
| Publisher version: | http://dx.doi.org/10.1007/s10856-014-5173-9 |
| Language: | English |
| Additional information: | © The Author(s) 2014. This article is published with open access at Springerlink.com |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1420891 |
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