Widschwendter, M;
Apostolidou, S;
Raum, E;
Rothenbacher, D;
Fiegl, H;
Menon, U;
Stegmaier, C;
... Brenner, H; + view all
(2008)
Epigenotyping in peripheral blood cell DNA and breast cancer risk: A proof of principle study.
PLoS ONE
, 3
(7)
, Article e2656. 10.1371/journal.pone.0002656.
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Abstract
Epigenetic changes are emerging as one of the most important events in carcinogenesis. Two alterations in the pattern of DNA methylation in breast cancer (BC) have been previously reported; active estrogen receptor-α (ER-α) is associated with decreased methylation of ER-α target (ERT) genes, and polycomb group target (PCGT) genes are more likely than other genes to have promoter DNA hypermethylation in cancer. However, whether DNA methylation in normal unrelated cells is associated with BC risk and whether these imprints can be related to factors which can be modified by the environment, is unclear.
| Type: | Article |
|---|---|
| Title: | Epigenotyping in peripheral blood cell DNA and breast cancer risk: A proof of principle study |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0002656 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0002656 |
| Language: | English |
| Additional information: | © 2008 Widschwendter et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The work described in this manuscript was supported by The Eve Appeal and The Oak Foundation and grants from the European Union and the FWF Austrian Science Fund (awarded to M. Widschwendter) and by a grant from the Baden-Württemberg Ministry of Research, Science and Arts (awarded to H. Brenner). The funders did not play any role in the design or conduct of the study. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Womens Cancer |
| URI: | https://discovery.ucl.ac.uk/id/eprint/141828 |
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