Bentley, JP;
Asselbergs, FW;
Coffey, CS;
Hebert, PR;
Moore, JH;
Hillege, HL;
van Gilst, WH;
(2010)
Cardiovascular risk associated with interactions among polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems.
PLoS One
, 5
(9)
, Article e12757. 10.1371/journal.pone.0012757.
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Abstract
Vascular fibrinolytic balance is maintained primarily by interplay of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1). Previous research has shown that polymorphisms in genes from the renin-angiotensin (RA), bradykinin, and fibrinolytic systems affect plasma concentrations of both t-PA and PAI-1 through a set of gene-gene interactions. In the present study, we extend this finding by exploring the effects of polymorphisms in genes from these systems on incident cardiovascular disease, explicitly examining two-way interactions in a large population-based study.
| Type: | Article |
|---|---|
| Title: | Cardiovascular risk associated with interactions among polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0012757 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0012757 |
| Language: | English |
| Additional information: | © 2010 Bentley et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC2939877 |
| Keywords: | Adult, Aged, Bradykinin, Cardiovascular Diseases, European Continental Ancestry Group, Female, Follow-Up Studies, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Netherlands, Polymorphism, Genetic, Renin-Angiotensin System, Risk Factors, Tissue Plasminogen Activator |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1414411 |
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