Winston, GP;
Micallef, C;
Symms, MR;
Alexander, DC;
Duncan, JS;
Zhang, H;
(2014)
Advanced diffusion imaging sequences could aid assessing patients with focal cortical dysplasia and epilepsy.
Epilepsy Research
, 108
(2)
pp. 336-339.
10.1016/j.eplepsyres.2013.11.004.
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Abstract
Malformations of cortical development (MCD), particularly focal cortical dysplasia (FCD), are a common cause of refractory epilepsy but are often invisible on structural imaging. NODDI (neurite orientation dispersion and density imaging) is an advanced diffusion imaging technique that provides additional information on tissue microstructure, including intracellular volume fraction (ICVF), a marker of neurite density. We applied this technique in 5 patients with suspected dysplasia to show that the additional parameters are compatible with the underlying disrupted tissue microstructure and could assist in the identification of the affected area. The consistent finding was reduced ICVF in the area of dysplasia. In one patient, an area of reduced ICVF and increased fibre dispersion was identified that was not originally seen on the structural imaging. The focal reduction in ICVF on imaging is compatible with previous iontophoretic data in surgical specimens, was more conspicuous than on other clinical or diffusion images (supported by an increased contrast-to-noise ratio) and more localised than on previous DTI studies. NODDI may therefore assist the clinical identification and localisation of FCD in patients with epilepsy. Future studies will assess this technique in a larger cohort including MRI negative patients.
| Type: | Article |
|---|---|
| Title: | Advanced diffusion imaging sequences could aid assessing patients with focal cortical dysplasia and epilepsy |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.eplepsyres.2013.11.004 |
| Publisher version: | http://dx.doi.org/10.1016/j.eplepsyres.2013.11.004 |
| Language: | English |
| Additional information: | © 2013 The Authors. Published by Elsevier B.V. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use,distribution and reproduction in any medium, provided the original author and source are credited. |
| Keywords: | CNR, CSF, Diffusion imaging, Epilepsy surgery, FA, FCD, FLAIR, Focal cortical dysplasia, ICVF, ITG, MCD, MD, MFG, MRI, NODDI, Neurite density, ODI, PROPELLER, cerebrospinal fluid, contrast-to-noise ratio, fluid-attenuated inversion recovery, focal cortical dysplasia, fractional anisotropy, inferior temporal gyrus, intracellular volume fraction, magnetic resonance imaging, malformations of cortical development, mean diffusivity, middle frontal gyrus, neurite orientation dispersion and density imaging, orientation dispersion index, periodically rotated overlapping parallel lines with enhanced reconstruction |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1414187 |
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