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Hippocampal volume loss following childhood convulsive status epilepticus is not limited to prolonged febrile seizures.

Yoong, M; Martinos, MM; Chin, RF; Clark, CA; Scott, RC; (2013) Hippocampal volume loss following childhood convulsive status epilepticus is not limited to prolonged febrile seizures. Epilepsia , 54 (12) 2108 - 2115. 10.1111/epi.12426. Green open access

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Abstract

Childhood convulsive status epilepticus (CSE), in particular prolonged febrile seizures (PFS), has been linked with mesial temporal sclerosis (MTS). Previous studies have shown that hippocampal injury occurs in the acute phase immediately following CSE, but little is known about the longer term evolution of such injury. This study aimed to investigate the longer term outcome of childhood CSE with sequential magnetic resonance imaging (MRI) looking for progressive hippocampal injury during the first year post-CSE.

Type: Article
Title: Hippocampal volume loss following childhood convulsive status epilepticus is not limited to prolonged febrile seizures.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/epi.12426
Publisher version: http://dx.doi.org/10.1111/epi.12426
Language: English
Additional information: © 2013 The Authors. Epilepsia published by Wiley Periodicals, Inc. on behalf of International League Against Epilepsy. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: Epilepsy, Hippocampus, Mesial temporal sclerosis, Prolonged febrile seizures, Status epilepticus
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1408628
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