Hiester, BG;
Galati, DF;
Salinas, PC;
Jones, KR;
(2013)
Neurotrophin and Wnt signaling cooperatively regulate dendritic spine formation.
Molecular and Cellular Neuroscience
, 56
115 - 127.
10.1016/j.mcn.2013.04.006.
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Abstract
Dendritic spines are major sites of excitatory synaptic transmission and changes in their numbers and morphology have been associated with neurodevelopmental and neurodegenerative disorders. Brain-derived Neurotrophic Factor (BDNF) is a secreted growth factor that influences hippocampal, striatal and neocortical pyramidal neuron dendritic spine density. However, the mechanisms by which BDNF regulates dendritic spines and how BDNF interacts with other regulators of spines remain unclear. We propose that one mechanism by which BDNF promotes dendritic spine formation is through an interaction with Wnt signaling. Here, we show that Wnt signaling inhibition in cultured cortical neurons disrupts dendritic spine development, reduces dendritic arbor size and complexity, and blocks BDNF-induced dendritic spine formation and maturation. Additionally, we show that BDNF regulates expression of Wnt2, and that Wnt2 is sufficient to promote cortical dendrite growth and dendritic spine formation. Together, these data suggest that BDNF and Wnt signaling cooperatively regulate dendritic spine formation.
| Type: | Article |
|---|---|
| Title: | Neurotrophin and Wnt signaling cooperatively regulate dendritic spine formation |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.mcn.2013.04.006 |
| Publisher version: | http://dx.doi.org/10.1016/j.mcn.2013.04.006 |
| Language: | English |
| Additional information: | © 2013 The Authors. Published by Elsevier Inc. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| Keywords: | Wnt signaling, BDNF, Dendritic spine, Dendrite branching, Synapse |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1401927 |
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