Donoghue, HD;
(2013)
Insights into ancient leprosy and tuberculosis using metagenomics.
Trends in Microbiology
, 21
(9)
pp. 448-450.
10.1016/j.tim.2013.07.007.
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Abstract
Leprosy and tuberculosis were widespread in the past and remain significant diseases today. Comparison of ancient and modern genomes of Mycobacterium leprae and Mycobacterium tuberculosis gives insight into their evolution and a calibration of the timescale for observed changes. Recently, whole genome sequencing has revealed genotypes and mixed-strain infections.
| Type: | Article |
|---|---|
| Title: | Insights into ancient leprosy and tuberculosis using metagenomics |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.tim.2013.07.007 |
| Publisher version: | http://dx.doi.org/10.1016/j.tim.2013.07.007 |
| Language: | English |
| Additional information: | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Ancient DNA, Metagenomics, Microbial evolution, Mycobacterium leprae, Mycobacterium tuberculosis |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1401750 |
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