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Disentangling Steric and Electrostatic Factors in Nanoscale Transport Through Confined Space

Buchsbaum, SF; Mitchell, N; Martin, H; Wiggin, M; Marziali, A; Coveney, PV; Siwy, Z; (2013) Disentangling Steric and Electrostatic Factors in Nanoscale Transport Through Confined Space. Nano Letters , 13 (8) pp. 3890-3896. 10.1021/nl401968r. Green open access

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Abstract

The voltage-driven passage of biological polymers through nanoscale pores is an analytically, technologically, and biologically relevant process. Despite various studies on homopolymer translocation there are still several open questions on the fundamental aspects of pore transport. One of the most important unresolved issues revolves around the passage of biopolymers which vary in charge and volume along their sequence. Here we exploit an experimentally tunable system to disentangle and quantify electrostatic and steric factors. This new, fundamental framework facilitates the understanding of how complex biopolymers are transported through confined space and indicates how their translocation can be slowed down to enable future sensing methods.

Type: Article
Title: Disentangling Steric and Electrostatic Factors in Nanoscale Transport Through Confined Space
Open access status: An open access version is available from UCL Discovery
DOI: 10.1021/nl401968r
Publisher version: http://dx.doi.org/10.1021/nl401968r
Language: English
Additional information: Copyright © 2013 American Chemical Society. This is the author's accepted manuscript of this article.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/1399698
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