Lim, D-I;
Park, H-S;
Park, J-H;
Knowles, JC;
Gong, M-S;
(2013)
Application of high-strength biodegradable polyurethanes containing different ratios of biobased isomannide and poly (E-caprolactone) diol.
Journal of Bioactive and Compatible Polymers: Biomedical Applications
, 28
(3)
274 - 288.
10.1177/0883911513484572.
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Abstract
Biodegradable–biocompatible polyurethanes were prepared with fixed hexamethylene diisocyanate and varying ratios of isomannide and poly(ϵ-caprolactone) diol using a simple one-step polymerization without a catalyst. The polyurethane structures were confirmed by 1H-nuclear magnetic resonance, Fourier transform infrared spectroscopy, and gel permeation chromatography. The glass transition temperatures were determined by thermal analysis to be between 25°C and 30°C. Degradation tests performed at 37°C in phosphate buffer produced mass losses of 5%–10% after 8 weeks. After 5 days of culture, using osteoblastic cells, the relative cell number on all the polyurethane films was only slightly lower than that of an optimized tissue culture plastic. These polymers offer significant promise with a simplistic synthesis and controlled degradation.
| Type: | Article |
|---|---|
| Title: | Application of high-strength biodegradable polyurethanes containing different ratios of biobased isomannide and poly (E-caprolactone) diol |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1177/0883911513484572 |
| Publisher version: | http://dx.doi.org/10.1177/0883911513484572 |
| Language: | English |
| Additional information: | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/3.0/), which permits use, distribution, and reproduction in any medium, provided that that reuse is restricted to non-commercial purposes, i.e. research or educational use, and the original work is properly cited. |
| Keywords: | Biodegradable, biobased monomer, polyurethane, biocompatible, isomannide |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Biomaterials and Tissue Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1396222 |
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