Lafont, E;
Milhas, D;
Teissié, J;
Therville, N;
Andrieu-Abadie, N;
Levade, T;
Benoist, H;
(2010)
Caspase-10-dependent cell death in Fas/CD95 signalling is not abrogated by caspase inhibitor zVAD-fmk.
PLoS One
, 5
(10)
, Article e13638. 10.1371/journal.pone.0013638.
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Abstract
Upon CD95/Fas ligation, the initiator caspase-8 is known to activate effector caspases leading to apoptosis. In the presence of zVAD-fmk, a broad-spectrum caspase inhibitor, Fas engagement can also trigger an alternative, non-apoptotic caspase-independent form of cell death, which is initiated by RIP1. Controversy exists as to the ability of caspase-10 to mediate cell death in response to FasL (CD95L or CD178). Herein, the role of caspase-10 in FasL-induced cell death has been re-evaluated.
| Type: | Article |
|---|---|
| Title: | Caspase-10-dependent cell death in Fas/CD95 signalling is not abrogated by caspase inhibitor zVAD-fmk |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0013638 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0013638 |
| Language: | English |
| Additional information: | © 2010 Lafont et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC2964310 |
| Keywords: | Amino Acid Chloromethyl Ketones, Antigens, CD95, Blotting, Western, Caspase 10, Caspase Inhibitors, Cell Death, Cysteine Proteinase Inhibitors, Flow Cytometry, HeLa Cells, Humans, Jurkat Cells, Signal Transduction |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1394553 |
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