Manzoni, C;
Lewis, PA;
(2013)
Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies.
The FASEB Journal
, 27
(9)
3424 - 3429.
10.1096/fj.12-223842.
Abstract
The past decade has witnessed huge advances in our understanding of the genetics underlying Parkinson's disease. Identifying commonalities in the biological function of genes linked to Parkinson's provides an opportunity to elucidate pathways that lead to neuronal degeneration and eventually to disease. We propose that the genetic forms of Parkinson's disease largely associated with α-synuclein-positive neuropathology (SNCA, LRRK2, and GBA) are brought together by involvement in the autophagy/lysosomal pathway and that this represents a unifying pathway to disease in these cases.
| Type: |
Article
|
| Title: |
Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies. |
| Location: |
United States |
| Open access status: |
An open access version is available from UCL Discovery |
| DOI: |
10.1096/fj.12-223842 |
| Publisher version: |
http://dx.doi.org/10.1096/fj.12-223842 |
| Language: |
English |
| Additional information: |
This is an Open Access article distributed under the terms
of the Creative Commons Attribution 3.0 Unported (CC BY
3.0) (http://creativecommons.org/licenses/by/3.0/deed.
en_US) which permits unrestricted use, distribution, and
reproduction in any medium, provided the original work is
properly cited. |
| Keywords: |
GBA, LRRK2, Parkinson's disease, Animals, Autophagy, Humans, Lysosomes, Models, Biological, Nerve Degeneration, Parkinson Disease, alpha-Synuclein |
| UCL classification: |
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmacology |
| URI: |
https://discovery.ucl.ac.uk/id/eprint/1393937 |
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