Djordjevic, S;
Driscoll, PC;
(2013)
Targeting VEGF signalling via the neuropilin co-receptor.
Drug Discovery Today
, 18
(9-10)
447 - 455.
10.1016/j.drudis.2012.11.013.
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Abstract
The blockade of tumour vascularisation and angiogenesis continues to be a focus for drug development in oncology and other pathologies. Historically, targeting vascular endothelial growth factor (VEGF) activity and its association with VEGF receptors (VEGFRs) has represented the most promising line of attack. More recently, the recognition that VEGFR co-receptors, neuropilin-1 and -2 (NRP1 and NRP2), are also engaged by specific VEGF isoforms in tandem with the VEGFRs has expanded the landscape for the development of modulators of VEGF-dependent signalling. Here, we review the recent structural characterisation of VEGF interactions with NRP subdomains and the impact this has had on drug development activity in this area.
| Type: | Article |
|---|---|
| Title: | Targeting VEGF signalling via the neuropilin co-receptor. |
| Location: | UK |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.drudis.2012.11.013 |
| Publisher version: | http://dx.doi.org/10.1016/j.drudis.2012.11.013 |
| Language: | English |
| Additional information: | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1386313 |
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