Savtchenko, LP;
Sylantyev, S;
Rusakov, DA;
(2013)
Central synapses release a resource-efficient amount of glutamate.
Nature Neuroscience
, 16
(1)
10 - 12.
10.1038/nn.3285.
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Abstract
Why synapses release a certain amount of neurotransmitter is poorly understood. We combined patch-clamp electrophysiology with computer simulations to estimate how much glutamate is discharged at two distinct central synapses of the rat. We found that, regardless of some uncertainty over synaptic microenvironment, synapses generate the maximal current per released glutamate molecule while maximizing signal information content. Our result suggests that synapses operate on a principle of resource optimization.
| Type: | Article |
|---|---|
| Title: | Central synapses release a resource-efficient amount of glutamate. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/nn.3285 |
| Publisher version: | http://dx.doi.org/10.1038/nn.3285 |
| Language: | English |
| Additional information: | PMCID: PMC3605778 |
| Keywords: | Animals, Biophysics, Cerebellum, Computer Simulation, Dipeptides, Dose-Response Relationship, Drug, Electric Stimulation, Entropy, Excitatory Postsynaptic Potentials, Glutamic Acid, Hippocampus, Male, Models, Neurological, Monte Carlo Method, Mossy Fibers, Hippocampal, Nerve Fibers, Neurons, Patch-Clamp Techniques, Rats, Rats, Sprague-Dawley, Receptors, AMPA, Synapses |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1382787 |
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