UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Protection of organs other than the heart by remote ischemic conditioning

Candilio, L; Malik, A; Hausenloy, DJ; (2013) Protection of organs other than the heart by remote ischemic conditioning. Journal of Cardiovascular Medicine , 14 (3) pp. 193-205. 10.2459/JCM.0b013e328359dd7b. Green open access

[thumbnail of Hausenloy_JCM-D-12-00444 revision2_extracted.pdf]
Preview
Text
Hausenloy_JCM-D-12-00444 revision2_extracted.pdf

Download (714kB) | Preview

Abstract

Organ or tissue dysfunction due to acute ischemia–reperfusion injury (IRI) is the leading cause of death and disability worldwide. Acute IRI induces cell injury and death in a wide variety of organs and tissues in a large number of different clinical settings. One novel therapeutic noninvasive intervention, capable of conferring multiorgan protection against acute IRI, is ‘remote ischemic conditioning’ (RIC). This describes an endogenous protective response to acute IRI, which is triggered by the application of one or more brief cycles of nonlethal ischemia and reperfusion to one particular organ or tissue. Originally discovered as a therapeutic strategy for protecting the myocardium against acute IRI, it has been subsequently demonstrated that RIC may confer protection against acute IRI in a number of different noncardiac organs and tissues including the kidneys, lungs, liver, skin flaps, ovaries, intestine, stomach and pancreas. The discovery that RIC can be induced noninvasively by applying the RIC stimulus to the skeletal tissue of the upper or lower limb has facilitated its application to a number of clinical settings in which organs and tissues are at high risk of acute IRI. In this article, we review the experimental studies that have investigated RIC in organs and tissues other than the heart, and we explore the therapeutic potential of RIC in preventing organ and tissue dysfunction induced by acute IRI.

Type: Article
Title: Protection of organs other than the heart by remote ischemic conditioning
Open access status: An open access version is available from UCL Discovery
DOI: 10.2459/JCM.0b013e328359dd7b
Publisher version: http://dx.doi.org/10.2459/JCM.0b013e328359dd7b
Language: English
Additional information: This is a non-final version of an article published in final form in Candilio, L; Malik, A; Hausenloy, DJ; (2013) Protection of organs other than the heart by remote ischemic conditioning. Journal of Cardiovascular Medicine, 14 (3) pp. 193-205. doi:10.2459/JCM.0b013e328359dd7b.
Keywords: science & technology, life sciences & biomedicine, cardiac & cardiovascular systems, cardiovascular system & cardiology, cardiac & cardiovascular systems, ischemia, remote ischemic perconditioning, remote ischemic postconditioning, remote ischemic preconditioning, reperfusion, randomized-controlled-trial, acute kidney injury, abdominal aortic-aneurysm, myocardial infarct size, artery-bypass surgery, gut barrier function, acute-renal-failure, hind-limb ischemia, k-atp channels, reperfusion injury
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
URI: https://discovery.ucl.ac.uk/id/eprint/1378777
Downloads since deposit
449Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item