Hynds, RE;
Giangreco, A;
(2013)
Concise review: the relevance of human stem cell-derived organoid models for epithelial translational medicine.
Stem Cells
, 31
(3)
417 - 422.
10.1002/stem.1290.
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Abstract
Epithelial organ remodeling is a major contributing factor to worldwide death and disease, costing healthcare systems billions of dollars every year. Despite this, most fundamental epithelial organ research fails to produce new therapies and mortality rates for epithelial organ diseases remain unacceptably high. In large part, this failure in translating basic epithelial research into clinical therapy is due to a lack of relevance in existing preclinical models. To correct this, new models are required that improve preclinical target identification, pharmacological lead validation, and compound optimization. In this review, we discuss the relevance of human stem cell-derived, three-dimensional organoid models for addressing each of these challenges. We highlight the advantages of stem cell-derived organoid models over existing culture systems, discuss recent advances in epithelial tissue-specific organoids, and present a paradigm for using organoid models in human translational medicine.
| Type: | Article |
|---|---|
| Title: | Concise review: the relevance of human stem cell-derived organoid models for epithelial translational medicine |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/stem.1290 |
| Publisher version: | http://dx.doi.org/10.1002/stem.1290 |
| Language: | English |
| Additional information: | This is the peer reviewed version of the following article: Hynds, RE; Giangreco, A; (2013) Concise review: the relevance of human stem cell-derived organoid models for epithelial translational medicine. Stem Cells , 31 (3) 417 - 422, which has been published in final form at http://dx.doi.org/10.1002/stem.1290. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving'. |
| Keywords: | Cell Differentiation, Humans, Models, Biological, Organoids, Stem Cell Transplantation, Stem Cells, Translational Medical Research |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1378660 |
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