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Cadherins in collective cell migration of mesenchymal cells

Theveneau, E; Mayor, R; (2012) Cadherins in collective cell migration of mesenchymal cells. Current Opinion in Cell Biology , 24 (5) 677 - 684. 10.1016/j.ceb.2012.08.002. Green open access

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Abstract

Immunity, embryogenesis and tissue repair rely heavily on cell migration. Cells can be seen migrating as individuals or large groups. In the latter case, collectiveness emerges via cell-cell interactions. In migratory epithelial cell sheets, classic Cadherins are critical to maintain tissue integrity, to promote coordination and establish cell polarity. However, recent evidence indicates that mesenchymal cells, migrating in streams such as neural crest or cancer cells, also exhibit collective migration. Here we will explore the idea that Cadherins play an essential role during collective migration of mesenchymal cells.

Type: Article
Title: Cadherins in collective cell migration of mesenchymal cells
Location: UK
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ceb.2012.08.002
Publisher version: http://dx.doi.org/10.1016/j.ceb.2012.08.002
Language: English
Keywords: Animals, Cadherins, Cell Adhesion, Cell Movement, Cell Polarity, Mesoderm, Neural Crest
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/1377560
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