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The population genetics of cooperative gene regulation.

Stewart, AJ; Seymour, RM; Pomiankowski, A; Plotkin, JB; (2012) The population genetics of cooperative gene regulation. BMC Evolutionary Biology , 12 , Article 173. 10.1186/1471-2148-12-173. Green open access

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Abstract

Changes in gene regulatory networks drive the evolution of phenotypic diversity both within and between species. Rewiring of transcriptional networks is achieved either by changes to transcription factor binding sites or by changes to the physical interactions among transcription factor proteins. It has been suggested that the evolution of cooperative binding among factors can facilitate the adaptive rewiring of a regulatory network.

Type: Article
Title: The population genetics of cooperative gene regulation.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/1471-2148-12-173
Publisher version: http://dx.doi.org/10.1186/1471-2148-12-173
Language: English
Additional information: © 2012 Stewart et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. PMCID: PMC3537746
Keywords: Algorithms, Binding Sites, Evolution, Molecular, Gene Expression Regulation, Gene Regulatory Networks, Genetics, Population, Models, Genetic, Mutation Rate, Protein Binding, Selection, Genetic, Transcription Factors
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: https://discovery.ucl.ac.uk/id/eprint/1377512
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