Stewart, AJ;
Seymour, RM;
Pomiankowski, A;
Plotkin, JB;
(2012)
The population genetics of cooperative gene regulation.
BMC Evolutionary Biology
, 12
, Article 173. 10.1186/1471-2148-12-173.
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Abstract
Changes in gene regulatory networks drive the evolution of phenotypic diversity both within and between species. Rewiring of transcriptional networks is achieved either by changes to transcription factor binding sites or by changes to the physical interactions among transcription factor proteins. It has been suggested that the evolution of cooperative binding among factors can facilitate the adaptive rewiring of a regulatory network.
| Type: | Article |
|---|---|
| Title: | The population genetics of cooperative gene regulation. |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1186/1471-2148-12-173 |
| Publisher version: | http://dx.doi.org/10.1186/1471-2148-12-173 |
| Language: | English |
| Additional information: | © 2012 Stewart et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. PMCID: PMC3537746 |
| Keywords: | Algorithms, Binding Sites, Evolution, Molecular, Gene Expression Regulation, Gene Regulatory Networks, Genetics, Population, Models, Genetic, Mutation Rate, Protein Binding, Selection, Genetic, Transcription Factors |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1377512 |
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