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Evidence for different mechanisms of 'unhooking' for melphalan and cisplatin-induced DNA interstrand cross-links in vitro and in clinical acquired resistant tumour samples

Spanswick, VJ; Lowe, HL; Newton, C; Bingham, JP; Bagnobianchi, A; Kiakos, K; Craddock, C; ... Hartley, JA; + view all (2012) Evidence for different mechanisms of 'unhooking' for melphalan and cisplatin-induced DNA interstrand cross-links in vitro and in clinical acquired resistant tumour samples. BMC Cancer , 12 , Article 436. 10.1186/1471-2407-12-436. Green open access

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Abstract

DNA interstrand cross-links (ICLs) are critical lesions produced by several cancer chemotherapy agents including platinum drugs and nitrogen mustards. We have previously shown in haematological (multiple myeloma) and solid tumours (ovarian cancer) that clinical sensitivity to such agents can result from a defect in DNA ICL processing leading to their persistence. Conversely, enhanced repair can result in clinical acquired resistance following chemotherapy. The repair of ICLs is complex but it is assumed that the 'unhooking' step is common to all ICLs.

Type: Article
Title: Evidence for different mechanisms of 'unhooking' for melphalan and cisplatin-induced DNA interstrand cross-links in vitro and in clinical acquired resistant tumour samples
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/1471-2407-12-436
Publisher version: http://dx.doi.org/10.1186/1471-2407-12-436
Language: English
Additional information: PMCID: PMC3522549 © 2012 Spanswick et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Antineoplastic Agents, Cell Line, Tumor, Cisplatin, DNA, DNA Damage, DNA Repair, DNA Replication, Deoxycytidine, Drug Resistance, Neoplasm, Female, Histones, Homologous Recombination, Humans, Melphalan, Multiple Myeloma, Ovarian Neoplasms, Rad51 Recombinase, Signal Transduction
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > CRUK Cancer Trials Centre
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: https://discovery.ucl.ac.uk/id/eprint/1376718
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