Spanswick, VJ;
Lowe, HL;
Newton, C;
Bingham, JP;
Bagnobianchi, A;
Kiakos, K;
Craddock, C;
... Hartley, JA; + view all
(2012)
Evidence for different mechanisms of 'unhooking' for melphalan and cisplatin-induced DNA interstrand cross-links in vitro and in clinical acquired resistant tumour samples.
BMC Cancer
, 12
, Article 436. 10.1186/1471-2407-12-436.
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Abstract
DNA interstrand cross-links (ICLs) are critical lesions produced by several cancer chemotherapy agents including platinum drugs and nitrogen mustards. We have previously shown in haematological (multiple myeloma) and solid tumours (ovarian cancer) that clinical sensitivity to such agents can result from a defect in DNA ICL processing leading to their persistence. Conversely, enhanced repair can result in clinical acquired resistance following chemotherapy. The repair of ICLs is complex but it is assumed that the 'unhooking' step is common to all ICLs.
| Type: | Article |
|---|---|
| Title: | Evidence for different mechanisms of 'unhooking' for melphalan and cisplatin-induced DNA interstrand cross-links in vitro and in clinical acquired resistant tumour samples |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1186/1471-2407-12-436 |
| Publisher version: | http://dx.doi.org/10.1186/1471-2407-12-436 |
| Language: | English |
| Additional information: | PMCID: PMC3522549 © 2012 Spanswick et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Antineoplastic Agents, Cell Line, Tumor, Cisplatin, DNA, DNA Damage, DNA Repair, DNA Replication, Deoxycytidine, Drug Resistance, Neoplasm, Female, Histones, Homologous Recombination, Humans, Melphalan, Multiple Myeloma, Ovarian Neoplasms, Rad51 Recombinase, Signal Transduction |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > CRUK Cancer Trials Centre UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1376718 |
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