Curto, C;
Sakata, S;
Marguet, S;
Itskov, V;
Harris, KD;
(2009)
A simple model of cortical dynamics explains variability and state dependence of sensory responses in urethane-anesthetized auditory cortex.
Journal of Neuroscience
, 29
(34)
10600 - 10612.
10.1523/JNEUROSCI.2053-09.2009.
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Abstract
The responses of neocortical cells to sensory stimuli are variable and state dependent. It has been hypothesized that intrinsic cortical dynamics play an important role in trial-to-trial variability; the precise nature of this dependence, however, is poorly understood. We show here that in auditory cortex of urethane-anesthetized rats, population responses to click stimuli can be quantitatively predicted on a trial-by-trial basis by a simple dynamical system model estimated from spontaneous activity immediately preceding stimulus presentation. Changes in cortical state correspond consistently to changes in model dynamics, reflecting a nonlinear, self-exciting system in synchronized states and an approximately linear system in desynchronized states. We propose that the complex and state-dependent pattern of trial-to-trial variability can be explained by a simple principle: sensory responses are shaped by the same intrinsic dynamics that govern ongoing spontaneous activity.
| Type: | Article |
|---|---|
| Title: | A simple model of cortical dynamics explains variability and state dependence of sensory responses in urethane-anesthetized auditory cortex. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1523/JNEUROSCI.2053-09.2009 |
| Publisher version: | http://dx.doi.org/10.1523/JNEUROSCI.2053-09.2009 |
| Language: | English |
| Additional information: | This work is licensed under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The license allows you to copy, distribute, and transmit the work, as well as adapting it. However, you must attribute the work to the author (but not in any way that suggests that they endorse you or your use of the work), and cannot use the work for commercial purposes without prior permission of the author. If you alter or build upon this work, you can distribute the resulting work only under the same or similar license to this one. PMCID: PMC2861166 |
| Keywords: | Acoustic Stimulation, Anesthetics, Intravenous, Animals, Auditory Cortex, Electric Stimulation, Evoked Potentials, Auditory, Models, Neurological, Neural Pathways, Neurons, Nonlinear Dynamics, Pedunculopontine Tegmental Nucleus, Rats, Rats, Sprague-Dawley, Urethane |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1371971 |
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