NEIDLE, S;
TAYLOR, G;
ROBINS, A;
(1978)
STRUCTURE OF A PLATINUM(II) COMPLEX OF 1-BETA-D-ARABINOFURANOSYL)CYTOSINE.
ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE
, 34
(Part 6)
1838 - 1841.
10.1107/S0567740878006792.
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Abstract
The structure of a complex, arapen, formed between Pt ethylenediamine dichloride (PtenCl 2) and 1-(fl-Darabinofuranosyl) cytosine (ara-C) is described. The sugar puckering is C(2')-endo, and an intramolecular hydrogen bond connecting 0(2') to 0(5') in the sugar moiety is observed, a feature seen in the structure of neutral ara-C. The possible implications of the structure to reactivity studies of the complex with nucleic acid components are discussed. [Crystal data: (CI~H2~NsOsPtCI)+CI -, space group P21212, a = 24.440 (2), b = 10.388 (2), c = 6.700 (1) ,/~, Z = 4.]
| Type: | Article |
|---|---|
| Title: | STRUCTURE OF A PLATINUM(II) COMPLEX OF 1-BETA-D-ARABINOFURANOSYL)CYTOSINE |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1107/S0567740878006792 |
| Publisher version: | http://scripts.iucr.org/cgi-bin/paper?S05677408780... |
| Language: | English |
| Additional information: | Copyright © International Union of Crystallography |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1367871 |
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