Silva, E;
Scholze, M;
Kortenkamp, A;
(2007)
Activity of xenoestrogens at nanomolar concentrations in the E-Screen assay.
Environmental Health Perspectives
, 115
(Suppl )
91 - 97.
10.1289/ehp.9363.
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Abstract
Our studies illustrate the difficulties that may be encountered during the estimation of low doses in vivo. High statistical power is required when the underlying dose-response curves are shallow. Through the use of large sample sizes and numerous repeats, the experimental power of the E-Screen assay was sufficiently high to measure effect magnitudes of around 1-2% with reliability. However, such resources are usually not available for in vivo testing, with the consequence that the statistical detection limits are considerably higher. If this coincides with shallow dose-response curves in the low-effect range (which is normally not measurable in vivo), the limited resolving power of in vivo assays may seriously constrain low-dose testing.
| Type: | Article |
|---|---|
| Title: | Activity of xenoestrogens at nanomolar concentrations in the E-Screen assay |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1289/ehp.9363 |
| Publisher version: | http://dx.doi.org/10.1289/ehp.9363 |
| Language: | English |
| UCL classification: | UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1363923 |
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