Costello, DA;
Claret, M;
Al-Qassab, H;
Plattner, F;
Irvine, EE;
Choudhury, AI;
Giese, KP;
... Pedarzani, P; + view all
(2012)
Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity.
PLoS One
, 7
(2)
, Article e31124. 10.1371/journal.pone.0031124.
![[thumbnail of journal.pone.0031124.pdf]](https://discovery.ucl.ac.uk/style/images/fileicons/application_pdf.png) Preview |
PDF
journal.pone.0031124.pdf Download (794kB) |
Abstract
Diabetes mellitus is associated with cognitive deficits and an increased risk of dementia, particularly in the elderly. These deficits and the corresponding neurophysiological structural and functional alterations are linked to both metabolic and vascular changes, related to chronic hyperglycaemia, but probably also defects in insulin action in the brain. To elucidate the specific role of brain insulin signalling in neuronal functions that are relevant for cognitive processes we have investigated the behaviour of neurons and synaptic plasticity in the hippocampus of mice lacking the insulin receptor substrate protein 2 (IRS-2).
| Type: | Article |
|---|---|
| Title: | Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0031124 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0031124 |
| Language: | English |
| Additional information: | © 2012 Costello et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC3287998 |
| Keywords: | Animals, Brain, Diabetes Mellitus, Experimental, Disease Models, Animal, Electrophysiology, Female, Heterozygote, Hippocampus, Hyperglycemia, Insulin Receptor Substrate Proteins, Male, Mice, Mice, Knockout, Neuronal Plasticity, Neurons, Phosphorylation, Receptors, N-Methyl-D-Aspartate, Research Design, Synapses |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1362030 |
Archive Staff Only
 |
View Item |
