Shahban, SA; Brown, RA; Bozec, L; Cheema, U; (2009) Enhancing the mechanical properties of collagen by photo-chemical cross-linking. In: Abstracts of the Tissue and Cell Engineering Society (TCES) meeting 8-10 July 2009, Universities of Glasgow & Strathclyde. (pp. 96 - 96).

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Abstract

Cell survival within mechanically strong scaffolds is critical in the design of tissue engineered constructs. Collagen type I gels tend to be mechanically weak due to the low percentage of collagen with limited orientation and crosslinking. To enhance the properties of collagen type I gels we used the following approaches: a) plastically compress the collagen gel to increase the density and b) photochemically crosslink the gel using riboflavin as a photoinitiator and high intensity blue light. Following plastic compression both the collagen density and cell number increase 58-fold1. This study aims to assess mechanical properties and the degree of cell viability in different areas of the compressed gel following cross-linking. Patterns of cross-linking were also applied to induce anisotropic features to the gels

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