Shepherd, A; Brown, R; Bozec, L; (2009) Mimicking the body- a novel method of Cross-linking collagen to control scaffold design- implications on human tissue engineering. In: Abstracts of the Tissue and Cell Engineering Society (TCES) meeting 8-10 July 2009, Universities of Glasgow & Strathclyde. (pp. 100 - 100).

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Abstract

Scaffold design is an essential part of tissue engineering. Cross-linked collagen matrices are often used to increase the mechanical strength of scaffolds. The ability to create and control different patterns of cross-linking within a collagen matrix would allow manipulation of scaffold characteristics (e.g. anisotropy, strength and shape) in order to tailor the design of the scaffold more appropriately to different applications. Photochemical crosslinking using Riboflavin and blue light1 has the potential to create patterns of crosslinking throughout a matrix. If successful, it can have applications in more sophisticated scaffold creation such as crosslinked tubular structures for nerve and vascular engineering. This study will assess the suitability of this method for such an application.

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