Cheema, U;
Hadjipanayi, E;
Mudera, V;
Deng, D;
Liu, W;
Brown, RA;
(2011)
Endothelial cell migration and aggregation in response to hypoxia-induced signalling.
In:
Abstracts of the Tissue and Cell Engineering Society (TCES) meeting 28-30 July 2010, University of Manchester.
(pp. 5 - 5).
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Abstract
The vascularisation of any graft, engineered implant or injury site is a key factor for optimal repair and regeneration. New blood vessel formation is a physiological response to tissue hypoxia, through upregulation of angiogenic factor signalling. We engineered cell-mediated hypoxia in a convenient cell type, human dermal fibroblasts (HDFs), to form a population of Hypoxia-Induced Signalling (HIS) cells and showed that HIS responses by HDFs induce endothelial cell (EC) migration and tubule formation both in vitro and in vivo
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