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The Virtues of Youth and Maturity (in Dentate Granule Cells)

Lever, C; Burgess, N; (2012) The Virtues of Youth and Maturity (in Dentate Granule Cells). Cell , 149 (1) 18 - 20. 10.1016/j.cell.2012.02.038. Green open access

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Abstract

How does adult neurogenesis contribute to memory? Nakashiba and colleagues generated mutant mice in which synaptic output from older hippocampal granule cells was specifically blocked. Experiments with these mice reveal an unpredicted age-dependent specialization of function, demonstrating that recently born cells support pattern separation, whereas older cells support pattern completion.

Type: Article
Title: The Virtues of Youth and Maturity (in Dentate Granule Cells)
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.cell.2012.02.038
Publisher version: http://dx.doi.org/10.1016/j.cell.2012.02.038
Language: English
Additional information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PubMed ID: 22464319
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
URI: https://discovery.ucl.ac.uk/id/eprint/1347156
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