Chinoy, H;
Li, CK;
Platt, H;
Fertig, N;
Varsani, H;
Gunawardena, H;
Betteridge, Z;
... UK Adult Onset Myositis Immunogenetic Consortium and UK Juvenile; + view all
(2012)
Genetic association study of NF-κB genes in UK Caucasian adult and juvenile onset idiopathic inflammatory myopathy.
Rheumatology
, 51
(5)
794 -799.
10.1093/rheumatology/ker379.
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Abstract
Treatment-resistant muscle wasting is an increasingly recognized problem in idiopathic inflammatory myopathy (IIM). TNF-α is thought to induce muscle catabolism via activation of nuclear factor-kappa B (NF-κB). Several genes share homology with the NF-κB family of proteins. This study investigated the role of NF-κB-related genes in disease susceptibility in UK Caucasian IIM.
| Type: | Article |
|---|---|
| Title: | Genetic association study of NF-κB genes in UK Caucasian adult and juvenile onset idiopathic inflammatory myopathy |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/rheumatology/ker379 |
| Publisher version: | http://dx.doi.org/10.1093/rheumatology/ker379 |
| Language: | English |
| Additional information: | © The Author(s) 2011. Published by Oxford University Press on behalf of The British Society for Rheumatology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. PMCID: PMC3327167 |
| Keywords: | Adolescent, Adult, Aged, Alleles, European Continental Ancestry Group, Female, Genetic Association Studies, Genetic Predisposition to Disease, Genotype, Great Britain, Haplotypes, Histocompatibility Antigens Class II, Humans, Male, Middle Aged, Myositis, NF-kappa B, Polymorphism, Single Nucleotide, Tumor Necrosis Factor-alpha |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > ICH - Laboratory Management UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1335194 |
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