Molecular and phenotypic characterisation of paediatric glioma cell lines as models for preclinical drug development.

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Molecular and phenotypic characterisation of paediatric glioma cell lines as models for preclinical drug development.

Bax, DA; Little, SE; Gaspar, N; Perryman, L; Marshall, L; Viana-Pereira, M; Jones, TA; ... Jones, C; + view all (2009) Molecular and phenotypic characterisation of paediatric glioma cell lines as models for preclinical drug development. PLOS One , 4 (4) , Article e5209. 10.1371/journal.pone.0005209. Green open access

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Abstract

Although paediatric high grade gliomas resemble their adult counterparts in many ways, there appear to be distinct clinical and biological differences. One important factor hampering the development of new targeted therapies is the relative lack of cell lines derived from childhood glioma patients, as it is unclear whether the well-established adult lines commonly used are representative of the underlying molecular genetics of childhood tumours. We have carried out a detailed molecular and phenotypic characterisation of a series of paediatric high grade glioma cell lines in comparison to routinely used adult lines.

Type:	Article
Title:	Molecular and phenotypic characterisation of paediatric glioma cell lines as models for preclinical drug development.
Location:	United States
Open access status:	An open access version is available from UCL Discovery
DOI:	10.1371/journal.pone.0005209
Publisher version:	http://dx.doi.org/10.1371/journal.pone.0005209
Language:	English
Additional information:	© 2009 Bax et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. This research is supported by Cancer Research UK (C1178/A10294, C309/A2187, C309/A8274), the Oak Foundation (LM) and La Fondation de France (NG). We acknowledge NHS funding to the NIHR Biomedical Research Centre. Paul Workman is a Cancer Research UK Life Fellow. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Keywords:	Adult, Astrocytes, Biological Markers, Cell Line, Tumor, Child, Chromosome Aberrations, Drug Design, Enzyme Activation, Epigenesis, Genetic, Gene Expression Profiling, Glioma, Humans, Immunophenotyping, Loss of Heterozygosity, Mitogen-Activated Protein Kinases, Phenotype, Phosphatidylinositol 3-Kinases, Signal Transduction, Stem Cells
UCL classification:	UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI:	https://discovery.ucl.ac.uk/id/eprint/1326794