Panagopoulos, I;
Lilljebjorn, H;
Strombeck, B;
Hjorth, L;
Olofsson, T;
Johansson, B;
(2006)
MLL/GAS7 fusion in a pediatric case of t(11;17)(q23;p13)-positive precursor B-cell acute lymphoblastic leukemia.
Haematologica-Hematology Journal
, 91
(9)
1287 - 1288.
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Abstract
AML/GAS7, resulting from t(11;17)(q23;p13), has been reported in one case of treatment-related acute myeloid leukemia (AML). We present a de novo case of t(11;17)-positive pediatric acute lymphoblastic leukemia. Fluorescent in situ hybridization and reverse transcriptase polymerase chain reaction analyses revealed an MLL/GAS7 chimera identical to the one previously described in AML. The molecular genetic features of MLL/GAS7 and the clinical impact of t(11;17) are discussed.
| Type: | Article |
|---|---|
| Title: | MLL/GAS7 fusion in a pediatric case of t(11;17)(q23;p13)-positive precursor B-cell acute lymphoblastic leukemia |
| Open access status: | An open access version is available from UCL Discovery |
| Publisher version: | http://www.haematologica.org |
| Language: | English |
| Additional information: | This work is published under under a Creative Commons Attribution 3.0 License (CC BY 3.0): http://creativecommons.org/licenses/by/3.0/ |
| Keywords: | ALL, translocation, MLL, GAS7, fusion, MYELOID-LEUKEMIA, MLL/GRAF FUSION, CHEMOTHERAPY |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1314071 |
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