Tanton, C;
Weiss, HA;
Le Goff, J;
Changalucha, J;
Rusizoka, M;
Baisley, K;
Everett, D;
... Watson-Jones, D; + view all
(2011)
Correlates of HIV-1 Genital Shedding in Tanzanian Women.
PLOS ONE
, 6
(3)
, Article e17480. 10.1371/journal.pone.0017480.
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Abstract
Background: Understanding the correlates of HIV shedding is important to inform strategies to reduce HIV infectiousness. We examined correlates of genital HIV-1 RNA in women who were seropositive for both herpes simplex virus (HSV)-2 and HIV-1 and who were enrolled in a randomised controlled trial of HSV suppressive therapy (aciclovir 400 mg b.i.d vs. placebo) in Tanzania.Methodology: Samples, including a cervico-vaginal lavage, were collected and tested for genital HIV-1 and HSV and reproductive tract infections (RTIs) at randomisation and 6, 12 and 24 months follow-up. Data from all women at randomisation and women in the placebo arm during follow-up were analysed using generalised estimating equations to determine the correlates of cervico-vaginal HIV-1 RNA detection and load.Principal Findings: Cervico-vaginal HIV-1 RNA was detected at 52.0% of 971 visits among 482 women, and was independently associated with plasma viral load, presence of genital ulcers, pregnancy, bloody cervical or vaginal discharge, abnormal vaginal discharge, cervical ectopy, Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis, an intermediate bacterial vaginosis score and HSV DNA detection. Similar factors were associated with genital HIV-1 RNA load.Conclusions: RTIs were associated with increased presence and quantity of genital HIV-1 RNA in this population. These results highlight the importance of integrating effective RTI treatment into HIV care services.
| Type: | Article |
|---|---|
| Title: | Correlates of HIV-1 Genital Shedding in Tanzanian Women |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0017480 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0017480 |
| Language: | English |
| Additional information: | © 2011 Tanton et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding for the study was provided by the Wellcome Trust (066688, www.wellcome.ac.uk), the UK Medical Research Council (G0400456, www.mrc.ac.uk) and the UK Department for International Development (www.dfid.gov.uk). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
| Keywords: | HERPES-SIMPLEX-VIRUS, SEXUALLY-TRANSMITTED-DISEASES, RANDOMIZED CONTROLLED-TRIAL, PLACEBO-CONTROLLED TRIAL, BACTERIAL VAGINOSIS, INFECTED WOMEN, RISK-FACTORS, CERVICOVAGINAL SECRETIONS, HORMONAL CONTRACEPTION, INTERVENTION TRIALS |
| UCL classification: | UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1300186 |
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