Skumlien, Martine;
Jones, Darcy;
Mokrysz, Claire;
Lees, Rachel;
Petrilli, Katherine;
Ofori, Shelan;
Lawn, Will;
... Freeman, Tom P; + view all
(2025)
Longitudinal study of risk factors predicting cannabis use disorder in UK young adults and adolescents.
Communications Medicine
, 5
, Article 300. 10.1038/s43856-025-01018-y.
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Abstract
Background: Cannabis use disorder (CUD) affects up to 1 in 5 people who try cannabis. In order to develop effective interventions to prevent and treat CUD, it is important to identify the factors that predict it. This longitudinal study investigated whether eight potential risk factors predicted CUD levels at 12-month follow-up. Methods: Participants were 232 young adults (26-29 years) and adolescents (16-17 years) (48%/52% males/females) who took part in both the baseline and 12-month follow-up sessions of the London-based ‘CannTeen’ study. Half of the participants (n = 117) used cannabis 1-7 days/week at baseline and the other half had used cannabis maximum 10 times in their life. CUD was measured with the Mini Neuropsychiatric interview for DSM-5 CUD, which was used to categorise participants into no, mild, moderate, or severe CUD levels. Ordinal logistic regression was used to explore whether baseline CUD (yes/no), age-group, gender, days/week of cannabis use, problematic alcohol use, problematic tobacco use, past-year negative life events, and the COVID-19 lockdown predicted 12-month CUD levels in the full sample and in only those who used cannabis minimum once per week at baseline. Results: Here we show that adolescent age (odds ratio = 3.26, p < 0.001) and CUD at baseline (odds ratio = 45.15, p < 0.001) predict higher CUD levels at follow-up. We do not find evidence to support associations with other factors. The same pattern of results is found when including only participants who used cannabis at baseline. Conclusions: CUD prevention and treatment should be targeted towards adolescents, who have a significantly greater risk of CUD than young adults.
| Type: | Article |
|---|---|
| Title: | Longitudinal study of risk factors predicting cannabis use disorder in UK young adults and adolescents |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s43856-025-01018-y |
| Publisher version: | https://doi.org/10.1038/s43856-025-01018-y |
| Language: | English |
| Additional information: | © The Author(s), 2026. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Addiction, Cognitive neuroscience |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10221864 |
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