Alagaratnam, Jasmini; Bakewell, Nicholas; Kunisaki, Ken M; Mallon, Patrick WG; Burns, Fiona; Waters, Laura; Post, Frank A; ... Sabin, Caroline; + view all Alagaratnam, Jasmini; Bakewell, Nicholas; Kunisaki, Ken M; Mallon, Patrick WG; Burns, Fiona; Waters, Laura; Post, Frank A; Sachikonye, Memory; Doyle, Nicki; Vera, Jaime H; Winston, Alan; Sabin, Caroline; - view fewer (2025) Associations between plasma biomarkers and changes in cognitive function over two years in people with and without HIV. AIDS 10.1097/QAD.0000000000004435. (In press).

Preview

Text Burns_associations_between_plasma_biomarkers_and_changes.835.pdf Download (1MB) | Preview

Abstract

Objective: Chronic inflammation may be associated with cognitive disorders in people with HIV (PWH) on antiretroviral treatment (ART). We examine associations between cognitive function (CF) and plasma biomarkers measured in PWH and demographically-similar people without HIV in the POPPY study. // Design: Prospective longitudinal cohort study. // Methods: At baseline and 2-year follow-up, participants completed a cognitive test battery. Global T-scores were derived by averaging domain T-scores. We used linear regression to explore associations between changes in Global T-scores and log-transformed plasma biomarkers of neuronal injury, systemic inflammation and innate immune activation. We explored whether effects of biomarkers differed by HIV status. // Results: 349 participants were included (73% PWH, median [interquartile range, IQR] age 54 [50–60] years, 85% male, 95% white). Among PWH, 98% were on ART, 93% had HIV-RNA ≤ 50 copies/mL and median [IQR] CD4+ count was 627 [490,792] cells/mm3. Mean (standard deviation (SD)) baseline Global T-score was 47.7 (5.9) which increased to 48.9 (5.5) after a median [IQR] follow-up of 26 [24,29] months. Lower average increases in Global T-scores were seen in those with higher MIP-1α concentrations (parameter estimate: −0.27 [95%CI:–0.51,–0.03] /10% increase) and sCD14 (−0.17 [–0.30,–0.03]), though only MIP-1α (−0.46 [–0.58,–0.10]) remained significant after adjustment. There was no evidence that the associations differed by HIV status. // Conclusion: Higher MIP-1α and sCD14 showed small associations with lower average increases in Global T-scores, with no differences by HIV status or inflammatory clusters, highlighting the multifactorial influences on cognitive trajectories in people ageing with and without HIV.

Download activity - last month

Export as CSVJSONXML

Download activity - last 12 months

Export as CSVXMLJSON

Downloads by country - last 12 months

Export as CSVJSONXML

Archive Staff Only

View Item