Kirstein, Janine;
Rosenzweig, Rina;
De Los Rios, Paolo;
Genevaux, Pierre;
Adang, Charlotte;
Andreasson, Claes;
Balchin, David;
... Kampinga, Harm H; + view all
(2025)
J-domain proteins: from molecular mechanisms to diseases.
Cell Stress Chaperones
, Article 100142. 10.1016/j.cstres.2025.100142.
(In press).
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Abstract
J-domain proteins (JDPs) are known to drive the functional specificity of Hsp70 chaperone machines. Here we report on the latest findings presented at the third international JDP workshop held in 2025 in Gdansk, Poland. Investigators from many different disciplines, including structural biology, genetics, chemical biology, translational research, computational sciences and biophysics took part in the meeting. This article includes short summaries of the seminars presented by many of the speakers, which provided exciting new insights into the chaperone-dependent and chaperone-independent functions of JDPs, some of which go beyond Hsp70-dependent functions. We also provide a revised classification of members of the (human) JDP family that emerged from open discussion at the meeting. This workshop continues to serve as the premier venue for discussions of JDP evolution, structure, function and roles in health, aging and disease.
| Type: | Article |
|---|---|
| Title: | J-domain proteins: from molecular mechanisms to diseases |
| Location: | Netherlands |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.cstres.2025.100142 |
| Publisher version: | https://doi.org/10.1016/j.cstres.2025.100142 |
| Language: | English |
| Additional information: | For the purpose of open access, the author(s) has applied a Creative Commons Attribution (CC BY) licence to any Author Accepted Manuscript version arising from this submission. |
| Keywords: | Hsp70, J-domain proteins (JDPs), functional classification |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10219859 |
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