Prasad, Vivek Kumar;
Ogbonnaya, Chibueze;
Oh, Hannah;
Atkin, Andrew;
Kindred, Madison;
Shin, Min-Jeong;
Park, Dahyun;
... Hamer, Mark; + view all
(2026)
Association of Body Fatness With Hypertension, Dyslipidemia, and Myocardial Infarction in a Multinational Pooled Cohort.
Mayo Clinic Proceedings
10.1016/j.mayocp.2025.10.014.
(In press).
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Abstract
Objective: To investigate the association of dual-energy X-ray absorptiometry—measured body fat percentage (BF%) and trunk fat mass index (TFMI) with hypertension (HTN), dyslipidemia, and myocardial infarction (MI). Methods: The relationship between body fat parameters and cardiovascular disease (CVD) was studied across individuals in the same body mass index (BMI) group. Data from the UK Biobank, a multicountry large population-based study, and the US and Korean National Health and Nutrition Examination Surveys, generating nationally representative samples, were pooled and harmonized. This cross-sectional analysis included 30,520 women and 27,244 men aged 40 years or older. Results: A significant increase in relative risks (RRs) of HTN across BF% quintiles was seen in men with normal weight, overweight, and obesity (P≤.01) and in normal weight women (P<.001). The RRs of dyslipidemia for normal weight and overweight men and women significantly increased across BF% quintiles (P≤.002). The RRs of MI did not exhibit a trend across BF% quintiles for participants within various BMI categories. The RRs of HTN and dyslipidemia significantly increased across TFMI quintiles for men and women with normal weight, overweight, and obesity (P≤.007). In men with normal weight, overweight, and obesity, the RRs of MI significantly increased across TFMI quintiles (P≤.03). However, no trend was displayed in the RRs of MI for women in any BMI group. Conclusion: This analysis revealed a positive association of dual-energy X-ray absorptiometry—measured body fat parameters with CVDs for individuals in a specific BMI group. The findings highlight a need for policy changes to include directly measured body fatness in assessing CVD risk.
| Type: | Article |
|---|---|
| Title: | Association of Body Fatness With Hypertension, Dyslipidemia, and Myocardial Infarction in a Multinational Pooled Cohort |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.mayocp.2025.10.014 |
| Publisher version: | https://doi.org/10.1016/j.mayocp.2025.10.014 |
| Language: | English |
| Additional information: | © 2025 THE AUTHORS. Published by Elsevier Inc on behalf of Mayo Foundation for Medical Education and Research. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10219736 |
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