Cortese, Rosa;
Bianchi, Alessia;
De Stefano, Nicola;
(2025)
It Is Time to See MOGAD From a Different Perspective Than Multiple Sclerosis.
Neurology Open Access
, 1
(2)
, Article e000020. 10.1212/wn9.0000000000000020.
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Abstract
Disability accumulation independent of relapses is a hallmark of multiple sclerosis (MS) and is now formally recognized as progression independent of relapse activity (PIRA). This concept is a cornerstone of MS pathophysiology, shaping clinical trial endpoints and treatment paradigms.1,2 However, whether this framework applies equally to antibody-mediated disorders such as myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) remains unclear. MOGAD has emerged as a distinct clinical and imaging entity.3 Unlike MS, where diffuse and subclinical neurodegeneration contribute to gradual disability accumulation beyond clinical relapses, MOGAD has been perceived as more “relapse-dependent” disease. Yet, robust data confirming the absence of subclinical progression in MOGAD remain scarce, leaving key issues such as monitoring and long-term patient management unresolved.
| Type: | Article |
|---|---|
| Title: | It Is Time to See MOGAD From a Different Perspective Than Multiple Sclerosis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1212/wn9.0000000000000020 |
| Publisher version: | https://doi.org/10.1212/wn9.0000000000000020 |
| Language: | English |
| Additional information: | © 2025 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10219559 |
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