Ogbonnaya, Chibueze;
Kindred, Madison;
Lavie, Carl J;
Oh, Hannah;
Shin, Min-Jeong;
Sui, Xuemei;
Jaggers, Jason;
... Prasad, Vivek K; + view all
(2025)
Association Between Trunk Fat Mass Index and Diabetes in a Multinational Population.
Mayo Clinic Proceedings: Innovations, Quality & Outcomes
, 9
(5)
, Article 100658. 10.1016/j.mayocpiqo.2025.100658.
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Abstract
Objective: To examine the cross-sectional association between trunk fat mass index (TFMI) and diabetes across individuals within the same body mass index (BMI [calculated as the weight in kilograms divided by the height in meters squared]) categories in a multinational population. / / Participants and Methods: We harmonized and pooled data on 57,764 individuals aged 40 years and older from the United Kingdom, the United States, and South Korea. Trunk fat mass imaging was performed using a dual-energy X-ray absorptiometry device during 2015–2023 in the United Kingdom, 2011–2018 in the United States, and 2008–2011 in South Korea. The prevalence of diabetes was derived from the self-reported medical history. Additionally, plasma biochemistry analyses were conducted to update the number of participants with diabetes. / / Results: Among participants classified as having a normal weight based on BMI, the relative risks (RRs) of diabetes increased from TFMI quintiles 1 to 5 with the linear trend (P<.001). The risk of diabetes among individuals in TFMI quintile 5 was around 3 times greater than those in quintile 1 (men—RR, 3.06; 95% confidence interval [CI], 2.17–4.34; women—3.35; 95% CI, 2.08–5.39). This significant linear trend (P<.001) in RRs was also present in overweight and obese individuals (overweight men—RR, 1.92; 95% CI, 1.50–2.47; overweight women—RR, 2.25; 95% CI, 1.73–2.91; obese men—RR, 2.47; 95% CI, 1.83–3.35; obese women—2.79; 95% CI, 2.04–3.83). / / Conclusion: Within a specific BMI category, individuals with a high trunk fat mass are more likely to experience diabetes compared with those with lower levels of central fat.
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