Gil Izquierdo, Sara;
Fernández Pilar, Andrés;
Rios, Jaqueline Lourdes;
Lim, Khoon S;
Toh, Wei Seong;
Liu, Chaozong;
Gimona, Mario;
... Man, Kenny; + view all
(2025)
Advances in extracellular vesicle-based nanomedicine for regenerative orthopaedics.
Journal of Nanobiotechnology
10.1186/s12951-025-03906-w.
(In press).
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Abstract
The increasing prevalence of bone and cartilage injuries presents a persistent clinical challenge in orthopaedic medicine. Current standard-of-care approaches and regenerative strategies, including cell-based therapies and conventional biomaterials, remain suboptimal due to their limited capacity to precisely modulate the complex cellular and molecular mechanisms governing cartilage repair, bone remodelling, and osseointegration. Extracellular vesicles (EVs), nature's nanoscale mediators of intercellular communication, have recently emerged as powerful bioactive entities with immense potential to orchestrate tissue regeneration. This review critically examines the diverse and dynamic roles of EVs in orthopaedic repair, emphasizing their mechanistic contributions to osteogenesis, chondrogenesis, and osteochondral interface regeneration. We further highlight recent advances in bioengineering approaches designed to enhance EV therapeutic efficacy, including surface functionalization, cargo engineering, and biomaterial-based delivery systems. Finally, we discuss the advent of EV-mimetic nanoplatforms as next-generation therapeutics, underscoring their translational potential to overcome current clinical limitations. Collectively, this review highlights the transformative promise of EV-based and EV-inspired nanotechnologies in advancing the frontier of bone and cartilage regenerative medicine.
| Type: | Article |
|---|---|
| Title: | Advances in extracellular vesicle-based nanomedicine for regenerative orthopaedics |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1186/s12951-025-03906-w |
| Publisher version: | https://doi.org/10.1186/s12951-025-03906-w |
| Language: | English |
| Additional information: | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
| Keywords: | Bone, Cartilage, Extracellular vesicles, Nanomedicine, Orthopaedics, Osteoarthritis, Regenerative medicine |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10219429 |
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