Miller, TD;
Hickling, AL;
Wu, YI;
Zhou, JH;
Handel, AE;
Coutinho, E;
Pollak, TA;
... Rosenthal, CR; + view all
(2025)
CA2/3-dependent stability of frontal mnemonic representations predict episodic deficits in human amnesia.
Cell Reports
, 44
(11)
, Article 116527. 10.1016/j.celrep.2025.116527.
Preview |
Text
Miller_1-s2.0-S2211124725012987-main.pdf Download (5MB) | Preview |
Abstract
The hippocampus reconstructs past experiences by integrating sensory, perceptual, and conceptual information across a cortico-hippocampal autobiographical memory network. Here, in 18 human participants with amnesia, we decode the effects of bilateral focal hippocampal damage on distinct autobiographical representations using representational dissimilarity matrices (RDMs). Hippocampal pathology results in impaired generalized episodic memory retrieval RDM model fit in the left angular gyrus and in reduced distinct episodic memory RDM model fit in the right inferior frontal gyrus (rIFG), while right angular gyrus (rANG) and right orbitofrontal cortex (rOFC) fall below multiple correction thresholds. Trial-by-trial voxel-representational stability is reduced in the rANG, rIFG, and rOFC. The RDM model fits and mnemonic stability are predicted by total CA2/3 volumes. Trial-by-trial retrieval stability within the rOFC and rIFG predicts episodic memory performance, providing a direct neural correlation between hippocampal dysfunction, altered mnemonic representations, and amnesia.
| Type: | Article |
|---|---|
| Title: | CA2/3-dependent stability of frontal mnemonic representations predict episodic deficits in human amnesia |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.celrep.2025.116527 |
| Publisher version: | https://doi.org/10.1016/j.celrep.2025.116527 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | CP: neuroscience, amnesia, angular gyrus, autobiographical memory, cortico-hippocampal network, episodic memory, hippocampal subfields, hippocampus, inferior frontal gyrus, leucine-rich glioma-inactivated-1-limbic encephalitis, neural representations, orbitofrontal cortex, Humans, Amnesia, Memory, Episodic, Male, Female, Middle Aged, Adult, Magnetic Resonance Imaging, CA3 Region, Hippocampal, Aged, CA2 Region, Hippocampal, Prefrontal Cortex, Mental Recall |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10218849 |
Archive Staff Only
 |
View Item |
