Young, Mariel;
Richard, Daniel;
Grabowski, Mark;
Auerbach, Benjamin M;
de Bakker, Bernadette S;
Hagoort, Jaco;
Muthuirulan, Pushpanathan;
... Capellini, Terence D; + view all
(2022)
The developmental impacts of natural selection on human pelvic morphology.
Science Advances
, 8
(33)
, Article eabq4884. 10.1126/sciadv.abq4884.
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Abstract
Evolutionary responses to selection for bipedalism and childbirth have shaped the human pelvis, a structure that differs substantially from that in apes. Morphology related to these factors is present by birth, yet the developmental-genetic mechanisms governing pelvic shape remain largely unknown. Here, we pinpoint and characterize a key gestational window when human-specific pelvic morphology becomes recognizable, as the ilium and the entire pelvis acquire traits essential for human walking and birth. We next use functional genomics to molecularly characterize chondrocytes from different pelvic subelements during this window to reveal their developmental-genetic architectures. We then find notable evidence of ancient selection and genetic constraint on regulatory sequences involved in ilium expansion and growth, findings complemented by our phenotypic analyses showing that variation in iliac traits is reduced in humans compared to African apes. Our datasets provide important resources for musculoskeletal biology and begin to elucidate developmental mechanisms that shape human-specific morphology.
| Type: | Article |
|---|---|
| Title: | The developmental impacts of natural selection on human pelvic morphology |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1126/sciadv.abq4884 |
| Publisher version: | https://doi.org/10.1126/sciadv.abq4884 |
| Language: | English |
| Additional information: | Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
| Keywords: | Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, HUMAN ACCELERATED REGIONS, EARLY-LIFE, EVOLUTION, INTEGRATION, GENE, CONSTRAINT, PATTERNS, EVOLVABILITY, EXPRESSION, DYSPLASIA |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL SLASH UCL > Provost and Vice Provost Offices > UCL SLASH > Faculty of S&HS UCL > Provost and Vice Provost Offices > UCL SLASH > Faculty of S&HS > Dept of Anthropology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10218459 |
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