Brett, Charlie;
Gout, Ivan;
(2025)
The two faces of coenzyme A in cellular biology.
Free Radical Biology and Medicine
, 233
pp. 162-173.
10.1016/j.freeradbiomed.2025.03.025.
![[thumbnail of FRBM-D-24-03607_R1.pdf]](https://discovery.ucl.ac.uk/style/images/fileicons/text.png) |
Text
FRBM-D-24-03607_R1.pdf - Accepted Version Access restricted to UCL open access staff until 3 April 2026. Download (3MB) |
Abstract
Coenzyme A (CoA) is an essential cofactor present in all living cells, which plays critical roles in diverse biochemical processes, including cellular metabolism, signal transduction, regulation of gene expression, and the antioxidant response. This review summarizes current knowledge on the role of CoA and its metabolically active thioesters in promoting cellular growth and proliferation (pro-growth) and discusses emerging research on CoA's antioxidant properties that enhance cell survival (pro-survival).
| Type: | Article |
|---|---|
| Title: | The two faces of coenzyme A in cellular biology |
| Location: | United States |
| DOI: | 10.1016/j.freeradbiomed.2025.03.025 |
| Publisher version: | https://doi.org/10.1016/j.freeradbiomed.2025.03.02... |
| Language: | English |
| Keywords: | Antioxidant function, Cellular metabolism, Coenzyme A, Protein CoAlation, Signal transduction |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10217985 |
Archive Staff Only
 |
View Item |
